Source: http://hamiltonsportsxpress.ca/2013/08/18/paul-macintosh-to-join-hamilton-skating-club/
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Sunday, August 18, 2013
Paul MacIntosh to join Hamilton Skating Club - Hamilton SportsXpress
[unable to retrieve full-text content]Paul was the 11th figure skating coach to reach Level 5 certification; and there are only approximately 100 coaches across all sports in Canada certified at this level. Paul MacIntosh has coached many skaters to the national ...
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Thursday, August 15, 2013
Police kill La. bank hostage taker; 1 hostage dies
ST. JOSEPH, La. (AP) ? A man who took hostages at a bank in rural Louisiana shot the two remaining hostages, killing one of them, before being shot and killed by police, authorities said.
During negotiations with law enforcement late Tuesday, the suspect ? identified as 20-year-old Fuaed (FOO-od) Abdo Ahmed ? said he was going to kill the hostages, Louisiana State Police superintendent Col. Mike Edmonson said. State police then entered the building just before midnight Tuesday.
That's when Ahmed shot the two hostages and then state police shot and killed him, Edmonson said. Edmonson said the hostages were shot in the upper body. He did not have any other information on the condition of the second hostage who was shot.
The hostages were both shot with a handgun, but Edmonson said Ahmed was also armed with a rifle.
The gunman initially took two women and a man captive around 12:30 p.m. Tuesday at the Tensas State Bank branch in St. Joseph. He later released one of the female hostages.
Edmonson said authorities were able to put Ahmed on the phone with a friend in Alaska during negotiations and that was key in getting him to release one of the hostages. But Edmonson also said the man grew increasingly erratic as negotiations went on, sometimes hanging up on police.
Edmonson said Ahmed was a paranoid schizophrenic who believed a device had been implanted in his brain and that the situation was not a bank robbery attempt but a planned attack.
"He was mad at people that he said were mean to him," Edmonson said. "He had voices in his head."
But Edmonson said there was no indication Ahmed had any history with the bank employees and they did not know why he picked the bank. The bank sits across the street from a service station owned by Ahmed's family.
"These were good, God-fearing people," he said of the hostages.
The suspect also had a duffel bag that contained items he was going to torture the hostages with, Edmonson said.
"His intent was to inflict pain and kill these individuals," he said.
Source: http://news.yahoo.com/police-kill-la-bank-hostage-taker-1-hostage-082036250.html
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Wednesday, August 14, 2013
Hollywood studios say China resumes payments after tax settlement
LOS ANGELES (Reuters) - China has agreed to resume payments owed to the U.S. film industry after the two sides resolved a tax dispute, the Motion Picture Association of America, a trade group for Hollywood studios, said on Tuesday.
The MPAA said the China Film Group Corp, a state-owned distributor, had stopped payments to the Hollywood studios because of problems with a new value-added tax applied across China on August 1.
The MPAA did not say when the payments stopped, but the film trade publication Variety said they might have been withheld as far back as March and that the amount owed to Hollywood studios could exceed $200 million.
"We are pleased to hear that the Chinese government has addressed the matter and all money due will be paid in full," said MPAA chief executive and chairman Chris Dodd. "It is our understanding that the payment process has recommenced."
The Chinese group had wanted to deduct the tax from what the studios earn in ticket sales in what is now the second-biggest film market.
Under a 2012 agreement between the Chinese and U.S. governments, the American studios increased their share of revenue to 25 percent of the Chinese box office from a previous rate of between 13.5 percent and 17.5 percent.
Deducting the new tax would have cut the studios' take by 2 percentage points.
Prior to the 2012 agreement, U.S. studios had long complained of China's tight restrictions on foreign films, which they said helped fuel demand for pirated DVDs that are widely available in China.
(Reporting By Mary Milliken; Editing by Xavier Briand)
Source: http://news.yahoo.com/hollywood-studios-china-resumes-payments-tax-settlement-023156929.html
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Atlanta boy goes on transplant list after earlier refusal: family
By David Beasley
ATLANTA (Reuters) - A 15-year-old Atlanta boy went on the waiting list for a heart transplant two days after his family complained he was unfairly rejected because of past failure to take medicine and show up for doctor's appointments, his family told a TV station on Tuesday.
Anthony Stokes has an enlarged heart and could have less than six months to live without a transplant, his family said. Relatives told Atlanta television station WSB that Children's Healthcare of Atlanta Hospital had reversed course and added him to the wait list on Tuesday.
The family did not say why he was uncooperative, and the hospital would neither confirm or deny the reason, citing patient privacy.
"As we stated previously, a heart transplant evaluation is an ongoing process based on the patient and his or her family's ability to meet specific transplant criteria," the hospital said on Tuesday. "Our physician experts are continuing to work with this family to establish a care plan and determine the best next steps for the patient."
Stokes' mother, Melencia Hamilton, told the television station two days ago that hospital officials had refused to put Stokes on the transplant list because of fear he would not comply with medical requirements.
"They said they don't have any evidence that he would take his medicine or that he would go to his follow-ups," Hamilton told WSB on Sunday.
Family members did not respond to Reuters phone calls seeking comment.
Heart transplant patients can become seriously ill and even die if they miss even one day of medication, said Mariell Jessup, president of the American Heart Association.
Hospitals consider a variety of factors besides medical necessity in deciding whether to put a patient on a transplant waiting list, said Joel Newman, a spokesman for the non-profit group, United Network For Organ Sharing.
Among the considerations are whether patients understand the risk, whether they are likely to follow medication schedules and whether they can get to a doctor's office or clinic for regular follow-up care.
Patients can be placed on the waiting list by one transplant center but be turned down at another with different criteria, he added.
(Editing by Jane Sutton and Andre Grenon)
Source: http://news.yahoo.com/atlanta-boy-goes-transplant-list-earlier-refusal-family-220647011.html
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Tuesday, August 13, 2013
Vickers gets full ride with Michael Waltrip Racing
Brad Keselowski, left, leads Brian Vickers during the NASCAR Nationwide auto race, Saturday, Aug. 3, 2013, at Iowa Speedway in Newton, Iowa. Keselowski won the race and Vickers finished in third place. (AP Photo/Charlie Neibergall)
Brad Keselowski, left, leads Brian Vickers during the NASCAR Nationwide auto race, Saturday, Aug. 3, 2013, at Iowa Speedway in Newton, Iowa. Keselowski won the race and Vickers finished in third place. (AP Photo/Charlie Neibergall)
CHARLOTTE, N.C. (AP) ? Brian Vickers has a full-time ride again on the Sprint Cup Series.
Michael Waltrip Racing announced Tuesday that Vickers will drive the No. 55 Aaron's Toyota for a full Sprint Cup schedule beginning next season. Andrea Freeman, the vice president of marketing for Aaron's Inc., says the sponsorship deal is for both the 2014 and 2015 seasons.
Vickers said he's "ecstatic" about the decision.
"I feel like I've found a home here at MWR," Vickers told The Associated Press in a telephone interview. "I'm partnered with a great team. A lot of it is about chemistry. Sometimes it's hard to find that right mesh, but when you find it, you know it."
The 29-year-old Vickers has endured plenty of adversity the last three years.
His racing career was derailed in May 2010 when 11 races into the season doctors discovered blood clots in his legs and lungs. Two months later he underwent two procedures to close a hole in his heart and insert a stent into a vein in his left leg.
Vickers said at the time he didn't know if he'd recover, let alone drive a stock car again.
He was medically cleared to return to racing in 2011 but his team struggled and he finished a disappointing 25th in the point standings. After the season he was dealt another blow when Red Bull pulled out of Cup racing leaving Vickers without a full-time ride.
He's been racing part-time on the Cup Series ever since with MWR, sharing a ride with Mark Martin. He's running a full schedule on the Nationwide Series this year for Joe Gibbs Racing.
"It's been a while since I've had a ride, so this feels great," Vickers said with a laugh.
Vickers called the last few years of his life "a rollercoaster ride," but believes his best racing is ahead of him.
"I'm still in my 20s and have more than 10 years of experience and a lot of life lessons that I think will only contribute to more wisdom on the track and more success," he said.
Vickers said getting a full sponsorship deal like this would have made him happy regardless, but given his health problems in recent years it makes it extra special.
He said there were times he didn't know if anyone would ever take a chance on him again.
"Oh, of course," Vickers said. "Between everything that has happened between the health issues and being in the hospital to Red Bull shutting down, did it come to mind? Absolutely.
"But one thing I have learned is you have to live every day one day at a time. You have to make plans for the future but you also have to live in the moment, which is a difficult balance. I've learned that you have to appreciate what you have. That's where I am right now."
It's rare in today's NASCAR world when a driver gets a full-time sponsorship from a company, let alone a two-year deal like Vickers received.
But Aaron's Inc. feels like it made the right choice.
Freeman said she got to know Vickers ? and his inspirational story ? over the past few months and was convinced he was the right man to continue the company's involvement in NASCAR.
"We're really excited about the passion he brings to the sport and feel like he will be a great representative for our brand," Freeman said.
If Aaron's had any questions about Vickers' ability to race ? and more importantly, win ? he and the No. 55 team answered those last month when he won at New Hampshire, snapping a 75-race winless streak on the Cup Series.
"I don't know if made a difference in sealing the deal, but I'm sure it didn't hurt," Vickers said with a laugh.
Team owner Michael Waltrip called Vickers a perfect fit for his team.
"I love his tenacity," Waltrip said at a press conference Tuesday at the NASCAR Hall of Fame. "He just fights and he digs and he's calm. He's not one of those guys on the radio how loses his mind over things going wrong. He just tries to help his team. His ability to work with other drivers is big, too. He just totally gets it."
With sponsorship security at hand, Vickers is turning his attention toward new goals on the track.
"I'm thankful for Aaron's and their sponsorship," Vickers said. "Now we're going to see if we can go out and win a championship or two."
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A Smart Online Search Reveals Cheap Travel Deals | Content for ...
Word Count: 747 Date:
So, you've booked it. You're ready to execute your traveling plan? Well, now is a great time. You probably have many questions on what you need to know, but don't worry, this article can assist you. Listed below are some tips that will help you get started with your traveling aspirations.
If you plan to be travelling for more than a week, make accommodations for your pets. Your neighbor or sister-in-law may assure you that stopping by is not a hassle, but you should not place that obligation on them for any longer than a week. There are many kennels and vet offices that will be glad to feed, play with and even, bathe your pets.
Trust locals over the concierge. Unfortunately, many hotels and their concierge services have agreements with certain businesses to steer guests to them, regardless of whether or not it is in your best interest. Instead, scope out a place that looks like your style and ask other customers for additional recommendations.
If you are traveling with kids, have them bring toys and games for the ride. When kids are bored, not only will they bother you with constant questions about when you will get to the desired location, but you will also find yourself making more stops for bathroom breaks and fast-food, as they try to find ways to entertain themselves.
Keep a photo journal of a beloved stuffed animal When traveling with kids, make great memories and an awesome souvenir by taking pictures of your child and the stuffed animal doing fun things throughout the trip. At home, you can collect all the pictures and make them into a photo adventure book to remember your trip.
Limit the amount of luggage you take on your trip to a carry-on bag. Luggage has a nasty habit of getting lost in airports. Even if it does not get lost, you often spend an annoying amount of time waiting for it to show up on the luggage carrousel. Limiting the luggage you take to a single carry-on bag will eliminate this problem entirely.
When you are traveling overseas, make sure that you know and obey all of the local laws. The embassies and consulates can only help you so much. If you commit a crime on foreign soil, according to foreign law, your government will be unable to override those laws and you must submit to the punishment of that country's laws.
Business travel can seem overwhelming when you are on a budget. If you know you will be traveling for work often, make sure to have your travel plans done in advance. This will include all payments that need to be made while you are away. Planning ahead will help you to not worry the whole time you are gone.
Make your travel plans more affordable by tracking airfare with online services. Get an idea of what you would like to pay for your flight, put the location and the dates into the website and then wait until the fare goes down to your pre-selected price. You no longer have to keep checking every few days sincy you will get an email when the fare reaches your ideal price.
When booking airline travel, prices are generally lower on those flights that no one else is interested in taking. For example, very early morning or very late evening flights are generally the ones that are not as popular. While you may not get a good night's sleep, you will save a fair amount of money. In addition, if you fly to your destination on Monday and back home on Thursday, you can save money as well.
It is helpful to label your power cords when you are traveling. Most people travel with a lot of different electronic devices. Not all of them will need to be constantly plugged in, so many people invariably leave one of the cords behind. If you write your name and phone number on masking tape and wrap the tape around your power cord, you have a much better chance of getting it back.
Traveling is one of the greatest experiences one can have in life. The ability to meet new people, explore new places, and learn about new cultures is unprecedented. The tips in this article should serve you well on your exciting adventures.
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Monday, October 29, 2012
Cocktail achieves superconducting boost: High-performance material uses iron and selenium
ScienceDaily (Oct. 29, 2012) ? Physicists describe how they have synthesized a new material that belongs to the iron-selenide class of superconductors, called LixFe2Se2(NH3)y, in a paper about to be published in The European Physical Journal B. The work was carried out by Ernst-Wilhelm Scheidt from the University of Augsburg and colleagues. This material displays promising superconducting transition temperatures of 44 Kelvins (K) at ambient pressure, thus improving upon traditional copper-based high-temperature superconductors.
The ultimate goal of scientists developing such materials is to reach superconducting characteristics at temperatures above that of liquid nitrogen (77K), which is the benchmark temperature to make them attractive for applications.
Until now, superconductors based on iron and arsenic discovered in 2008 worked at 56K. As recently as 2010 attempts to develop other materials replacing arsenic with selenium yielded iron-selenium materials with an intercalation of potassium, rubidium, cesium or thalium. These materials, belonging to the family of iron chalcogenide materials, reached a superconducting temperature of 32 K.
The authors have now used a chemical synthesis method to intercalate lithium atoms between layers of iron and selenium. Similar to the way a cocktail would generate an exciting new flavour, stirring all these ingredients for several hours in liquid ammonia produced exciting new superconducting properties. They found that these properties are controlled by electronic doping and expansion of the iron-selenium material's lattice structure, which is gained by intercalating the lithium-based electronic donor molecules.
Unlike previous attempts, the authors showed in this study that these materials can be successfully synthesised with a remarkable degree of purity. In addition, the fraction of the material that is superconductive was almost 80 percent, the highest reported for materials in the intercalated iron chalcogenides family.
Going one step further, the authors also showed that using sodium instead of lithium will further increase the superconducting temperature to 45.5 K.
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- E. -W. Scheidt, V. R. Hathwar, D. Schmitz, A. Dunbar, W. Scherer, F. Mayr, V. Tsurkan, J. Deisenhofer, A. Loidl. Superconductivity at Tc = 44 K in LixFe2Se2(NH3)y. The European Physical Journal B, 2012; 85 (8) DOI: 10.1140/epjb/e2012-30422-6
Note: If no author is given, the source is cited instead.
Disclaimer: Views expressed in this article do not necessarily reflect those of ScienceDaily or its staff.
Source: http://feeds.sciencedaily.com/~r/sciencedaily/~3/Z-JZgqXkx_A/121029081843.htm
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Friday, October 26, 2012
AB Lietuvos Dujos Sets LNG Terminal Related ... - LNG World News
National Control Commission for Prices and Energy set the newly adjusted AB Lietuvos Dujos natural gas transmission and distribution price caps (effective from 1 January 2013 to 31 December 2013) and approved the adjusted version of AB Lietuvos Dujos long-term programme (for 2009?2013) of investments in gas transmission and distribution systems.
The natural gas transmission price cap (effective from 1 January 2013) was set at LTL 44.26* / 1000 m3, and the natural gas distribution price cap was set at LTL 179.33 / 1000 m3.
Following the price caps that were set by the NCCPE, the Board of Directors of AB Lietuvos Dujos will subsequently adopt its decision regarding the specific natural gas transmission and distribution service tariffs (effective from 1 January 2013). Then the tariffs will be submitted to the NCCPE for review and final approval.
NCCPE also set the Liquefied Natural Gas Terminal related extra tariff component for the year 2013 to cover part of the costs of the installation of the facilities and the connector of the prospective LNGT.
The aforesaid tariff component was set at LTL 37.53 / 1000 m3. According to the Description of procedures for the administration of funds allocated to cover the costs (or part thereof) related to the construction and operation of the Liquefied Natural Gas Terminal, the LNGT infrastructure and connector (as adopted by the NCCPE), from 2013, the LNGT funds (based on the aforesaid LNGT-extra tariff component) will have to be paid by all users of the Gas Transmission System.
According to the Law on the Liquefied Natural Gas Terminal, the entity appointed in charge of the administration of the LNGT funds, the Transmission System Operator ? AB Lietuvos Dujos, will collect the LNGT funds and transfer them to the beneficiary ? the company that was appointed by the Government to implement the LNGT Project (AB Klaipedos Nafta).
* LTL 3.45 = EUR 1
LNG World News Staff, October 26, 2012; Image: AB Lietuvos Dujos
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If Mitt Romney Loses, Blame All the Time the GOP Wasted This Cycle (Atlantic Politics Channel)
Dreaming Feathers
When people start to meet eachother in dreams... reality seems to twist around. Two soulmates have found eachother in there sleep... but daylight is still keeping them apart...
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Monday, October 15, 2012
Intensive care 'trauma lingers' | Human Health and Science
Source: http://www.humanhealthandscience.com/intensive-care-trauma-lingers/news
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Obama embraces economic record in new commercial
FILE - In this Oct. 3, 2012, file photo, Republican presidential candidate Mitt Romney and President Barack Obama wave to the audience during the first presidential debate at the University of Denver in Denver. The sixth "town hall" style presidential debate will bring Obama and Romney to Hofstra University on New York?s Long Island Tuesday, Oct. 16, 2012. They?ll take questions from undecided voters selected by Gallup. (AP Photo/Charlie Neibergall, File)
FILE - In this Oct. 3, 2012, file photo, Republican presidential candidate Mitt Romney and President Barack Obama wave to the audience during the first presidential debate at the University of Denver in Denver. The sixth "town hall" style presidential debate will bring Obama and Romney to Hofstra University on New York?s Long Island Tuesday, Oct. 16, 2012. They?ll take questions from undecided voters selected by Gallup. (AP Photo/Charlie Neibergall, File)
President Barack Obama makes phone calls to volunteers at an Organizing for America field office with Alexa Kissinger, left, and, Suzanne Stern, right, Sunday, Oct. 14, 2012, in Williamsburg, Va. (AP Photo/Carolyn Kaster)
Republican presidential candidate and former Massachusetts Gov. Mitt Romney campaigns in front of The Golden Lamb Inn and Restaurant in Lebanon, Ohio, Saturday, Oct. 13, 2012. (AP Photo/Charles Dharapak)
President Barack Obama makes phone calls to volunteers at an Obama campaign office with Suzanne Stern, right, Sunday, Oct. 14, 2012, in Williamsburg, Va. (AP Photo/Carolyn Kaster)
Republican presidential candidate and former Massachusetts Gov. Mitt Romney picks up a baby as he campaigns at The Golden Lamb restaurant in Lebanon, Ohio, Saturday, Oct. 13, 2012. (AP Photo/Charles Dharapak)
WILLIAMSBURG, Va. (AP) ? With the economy showing some signs of improvement three weeks before Election Day, President Barack Obama on Monday laid down a full embrace of the economic record many Republicans say is his biggest weakness.
The president's first act in this critical campaign week was to announce a new battleground state advertisement featuring voters discussing the ways their economic conditions have improved during his term. The ad was hitting the airwaves as Obama and Republican challenger Mitt Romney huddled in intense preparation for their second debate as polls show a closely fought campaign.
"This race is tied," Obama said in an appeal to supporters asking them to donate at least $5 to his re-election effort. He promised to be "fighting" for the election on the debate stage Tuesday night ? something many of his supporters thought he did too little of in his first face-off with Romney.
GOP vice presidential nominee Paul Ryan lambasted Obama's handling of the deficit during an appearance Monday in Ryan's home state of Wisconsin. He pointed to a digital scoreboard his campaign set up at the far end of Carroll University's field house that tracked the growth of the nation's deficit in real time.
"Look at how fast those numbers are running," Ryan said. "We know without a shred of doubt that we have consigned the next generation to this path of debt."
He acknowledged that Obama inherited "a tough situation" when he took office but argued the president has only made things worse. He touted Romney's plan to cut taxes by 20 percent across the board as the path back to economic growth.
Even as polls show the race tightening nationally and in battleground states, Obama's campaign aides say they are encouraged by public and private surveys showing voters growing more confident about the direction of the economy. Those trends are behind the new 30-second spot the campaign is running in Colorado, Iowa, Nevada and Virginia.
"Stick with this guy," a gravelly voiced man says at the end of the commercial in a point Obama hopes wavering voters will embrace. A second ad targeted at Ohio voters features former astronaut and Sen. John Glenn touting Obama's character and economic record.
Aides argue that some voters got a psychological boost when the unemployment rate fell below 8 percent last month for the first time since Obama's inauguration. But the campaign says it puts more stock in economic indicators showing an increase in consumer confidence and retail spending, which indicate shifts in voter behavior.
Retail sales rose 1.1 percent last month, the Commerce Department said Monday. That followed a 1.2 percent increase in August, which was revised slightly higher. Both were the largest gains since October 2010. The Commerce Department also announced Monday that American companies restocked their shelves at a solid pace of 0.6 percent in August.
Still, with millions of Americans still out of work, the campaign is trying to walk a fine line between touting economic gains and acknowledging that many voters are still struggling.
Obama campaign spokeswoman Jennifer Psaki said the president would seek to run on his economic record, not away from it, during Tuesday's debate.
"He would be happy to spend the entire debate talking about their visions for the middle class," Psaki told reporters gathered in Williamsburg, Va., where Obama and his advisers were in the midst of an intense, three-day "debate camp" at a golf resort.
Obama's campaign, seeking to rebound from a dismal first debate, promised a more energetic president would take the stage Tuesday at Hofstra University in Hempstead, N.Y. Romney's team aimed to build on a commanding opening debate that gave the Republican new life in a White House race that had once appeared to be slipping away from him.
"The debate was huge and we've seen our numbers move all across the country," Romney's wife, Ann, said in an interview on Philadelphia radio station WPHT. She talked about the larger crowds her husband has been drawing in the aftermath of that first face-off. "That's what you call momentum," she said.
Early voting is already under way in dozens of states, including some battlegrounds, giving the candidates little time to recover from any slipups.
Much of the pressure in the coming debate will be on Obama, who aides acknowledge showed up at the first face-off with less practice ? and far less energy ? than they had wanted. Romney, who has made no secret of the huge priority his campaign puts on the debates, practiced Monday at a hotel near his home in Massachusetts.
Romney's advisers suggested the Republican nominee would continue to moderate his message ? in tone, if not substance ? as he did in the Oct. 3 meeting to help broaden his appeal to the narrow slice of undecided voters. In recent days, Romney has promised his tax plan would not benefit the wealthy, emphasized his work with Democrats as Massachusetts governor and downplayed plans to curtail women's abortion rights.
Ann Romney focused on the struggles women face in her radio interview. "The numbers don't lie and what the numbers tell us is that more women have been hurt by this economy than men, more women are unemployed, and more women have fallen into poverty in the last four years," she said. "We do hear their voices."
During debate preparations, aides are working on tailoring that message to a debate format. They're also working on balancing aggressive tactics with the debate's town-hall format, which often requires candidates to show a connection with questioners from the audience.
Romney's top-flight donors are meeting at New York's tony Waldorf Astoria hotel through Wednesday, getting a chance to mingle with Ryan and attend strategy briefings and policy discussions with senior Romney aides.
The retreat appears to be a scaled-down version of a posh Park City, Utah, gathering this summer for Romney's most generous contributors. There, Romney officials hosted campaign updates and set ambitious fundraising goals for the general election.
___
Obama ad: http://tinyurl.com/ck3oblq
___
Pickler reported from Washington. Associated Press writer Steve Peoples in Belmont, Mass., contributed to this report.
___
Follow Julie Pace at http://twitter.com/jpaceDC
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Of mice and men
![[ Back to EurekAlert! ]](https://lh3.googleusercontent.com/blogger_img_proxy/AEn0k_suT4gSdvXVewnrEs8Z8HzC64FZznC-OiQ-q7OUznipqNcwZ6OjL54d8ylvfYRBhnm6IK8izOrXSQWoZhR9rqDm8ZaYhiXNkRM0PKzBWkc=s0-d){kind=small}
Public release date: 15-Oct-2012[ | E-mail |
Share ] Contact: Veronika Sexl
veronika.sexl@vetmeduni.ac.at
43-125-077-2910
University of Veterinary Medicine -- Vienna
So-called Anaplastic Large Cell Lymphoma (ALCL) is even less attractive in real life than it is on paper. It is a highly aggressive type of lymphoma that generally occurs in children and young adults and that has to date proven extremely difficult to treat. It has long been known that ALCL patients frequently show a genetic alteration (a translocation) that causes expression of nucleophosmin-anaplastic lymphoma kinase (NPM-ALK), a gene known to be capable of giving rise to cancer. But how the NPM-ALK gene works has to date remained largely a matter of conjecture.
Working in a mouse model for lymphoma, Karoline Kollmann in Veronika Sexl's group at the University of Veterinary Medicine, Vienna and colleagues in the Ludwig Boltzmann Institute for Cancer Research and the Medical University of Vienna were able to show that the development of lymphoma is absolutely dependent on the "Platelet derived growth factor receptor B" (PDGFRB), a protein already associated with the growth of other types of tumour. They demonstrated that the effect was direct, with NPM-ALK stimulating the production of the transcription factors JUN and JUNB, which bind to and activate the PDGFRB promoter. And importantly they were able to show that inhibition of PDGFRB with the drug imatinib was able to extend dramatically the survival of mice with this kind of lymphoma.
In human patients, ALCL is traditionally treated with crizotinib, a drug that directly inhibits the NPM-ALK protein. The major problem is that the patients tend to relapse and their chances of survival are extremely poor. Based on the results from the imatinib tests in mice it seemed conceivable that the use of this drug might improve the prognosis of patients who do not or no longer respond to crizotinib therapy. The scientists obtained ethical approval and informed consent to attempt imatinib treatment of an ALCL patient who had not responded to conventional chemotherapy and had relapsed after transplantation of stem cells. Remarkably, the patient improved immediately upon imatinib treatment: after ten days he was in complete remission and he is still alive and again working 22 months later.
The idea of inhibiting PDGFRB in ALCL is novel and potentially of great therapeutic importance. Kollmann is naturally extremely excited by the implications of the results. "The patient had essentially run out of options and would have died a long time ago. But thanks to the indications from our mouse work that inhibiting PDGFRB could prevent growth of this type of tumour he is still alive. This new type of therapy could significantly prolong patient survival."
Intriguingly, the researchers have also found that PDGRFB is also present in ALCL patients without the translocation that leads to NPM-ALK expression. Whether the PDGRFB protein is required for the development of tumours in such patients is not yet clear but it is possible that a combined crizotinib / imatinib therapy might be more widely applicable, providing hope for patients suffering from other types of lymphoma.
The paper "Identification of PDGFR blockade as a rational and highly effective therapy for NPM-ALK driven lymphomas" by Daniela Laimer, Helmut Dolznig, Karoline Kollmann, Paul W. Vesely, Michaela Schlederer, Olaf Merkel, Ana-Iris Schiefer, Melanie R. Hassler, Susi Heider, Lena Amenitsch, Christiane Thallinger, Philipp B. Staber, Ingrid Simonitsch-Klupp, Matthias Artaker, Sabine Lagger, Stefano Pileri, Pier Paolo Piccaluga, Peter Valent, Katia Messana, Indira Landra, Thomas Weichhart, Sylvia Knapp, Medhat Shehata, Maria Todaro, Veronika Sexl, Gerald Hfler, Roberto Piva, Enzo Medico, Bruce A. Riggeri, Mangeng Cheng, Robert Eferl, Gerda Egger, Josef M. Penninger, Ulrich Jaeger, Richard Moriggl, Giorgio Inghirami and Lukas Kenner is published in the current issue of "Nature Medicine". The first four authors contributed equally to the work.
###
Abstract of the scientific article online (full text for a fee or with a subscription): http://dx.doi.org/10.1038/nm.2966
About the University of Veterinary Medicine, Vienna
The University of Veterinary Medicine, Vienna is the only academic and research institution in Austria that focuses on the veterinary sciences. About 1000 employees and 2300 students work on the campus in the north of Vienna, which also houses the animal hospital and various spin-off-companies. http://www.vetmeduni.ac.at
Scientific contact:
Prof. Veronika Sexl
Institute of Pharmacology and Toxicology
University of Veterinary Medicine, Vienna
T +43 1 25077-2910
Veronika.Sexl@vetmeduni.ac.at
Distributed by:
Klaus Wassermann
Public Relations/Science Communication
University of Veterinary Medicine, Vienna
T +43 1 25077-1153
Klaus.Wassermann@vetmeduni.ac.at
[ | E-mail | Share ] ?
AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.
Public release date: 15-Oct-2012[ | E-mail |
Share ] Contact: Veronika Sexl
veronika.sexl@vetmeduni.ac.at
43-125-077-2910
University of Veterinary Medicine -- Vienna
So-called Anaplastic Large Cell Lymphoma (ALCL) is even less attractive in real life than it is on paper. It is a highly aggressive type of lymphoma that generally occurs in children and young adults and that has to date proven extremely difficult to treat. It has long been known that ALCL patients frequently show a genetic alteration (a translocation) that causes expression of nucleophosmin-anaplastic lymphoma kinase (NPM-ALK), a gene known to be capable of giving rise to cancer. But how the NPM-ALK gene works has to date remained largely a matter of conjecture.
Working in a mouse model for lymphoma, Karoline Kollmann in Veronika Sexl's group at the University of Veterinary Medicine, Vienna and colleagues in the Ludwig Boltzmann Institute for Cancer Research and the Medical University of Vienna were able to show that the development of lymphoma is absolutely dependent on the "Platelet derived growth factor receptor B" (PDGFRB), a protein already associated with the growth of other types of tumour. They demonstrated that the effect was direct, with NPM-ALK stimulating the production of the transcription factors JUN and JUNB, which bind to and activate the PDGFRB promoter. And importantly they were able to show that inhibition of PDGFRB with the drug imatinib was able to extend dramatically the survival of mice with this kind of lymphoma.
In human patients, ALCL is traditionally treated with crizotinib, a drug that directly inhibits the NPM-ALK protein. The major problem is that the patients tend to relapse and their chances of survival are extremely poor. Based on the results from the imatinib tests in mice it seemed conceivable that the use of this drug might improve the prognosis of patients who do not or no longer respond to crizotinib therapy. The scientists obtained ethical approval and informed consent to attempt imatinib treatment of an ALCL patient who had not responded to conventional chemotherapy and had relapsed after transplantation of stem cells. Remarkably, the patient improved immediately upon imatinib treatment: after ten days he was in complete remission and he is still alive and again working 22 months later.
The idea of inhibiting PDGFRB in ALCL is novel and potentially of great therapeutic importance. Kollmann is naturally extremely excited by the implications of the results. "The patient had essentially run out of options and would have died a long time ago. But thanks to the indications from our mouse work that inhibiting PDGFRB could prevent growth of this type of tumour he is still alive. This new type of therapy could significantly prolong patient survival."
Intriguingly, the researchers have also found that PDGRFB is also present in ALCL patients without the translocation that leads to NPM-ALK expression. Whether the PDGRFB protein is required for the development of tumours in such patients is not yet clear but it is possible that a combined crizotinib / imatinib therapy might be more widely applicable, providing hope for patients suffering from other types of lymphoma.
The paper "Identification of PDGFR blockade as a rational and highly effective therapy for NPM-ALK driven lymphomas" by Daniela Laimer, Helmut Dolznig, Karoline Kollmann, Paul W. Vesely, Michaela Schlederer, Olaf Merkel, Ana-Iris Schiefer, Melanie R. Hassler, Susi Heider, Lena Amenitsch, Christiane Thallinger, Philipp B. Staber, Ingrid Simonitsch-Klupp, Matthias Artaker, Sabine Lagger, Stefano Pileri, Pier Paolo Piccaluga, Peter Valent, Katia Messana, Indira Landra, Thomas Weichhart, Sylvia Knapp, Medhat Shehata, Maria Todaro, Veronika Sexl, Gerald Hfler, Roberto Piva, Enzo Medico, Bruce A. Riggeri, Mangeng Cheng, Robert Eferl, Gerda Egger, Josef M. Penninger, Ulrich Jaeger, Richard Moriggl, Giorgio Inghirami and Lukas Kenner is published in the current issue of "Nature Medicine". The first four authors contributed equally to the work.
###
Abstract of the scientific article online (full text for a fee or with a subscription): http://dx.doi.org/10.1038/nm.2966
About the University of Veterinary Medicine, Vienna
The University of Veterinary Medicine, Vienna is the only academic and research institution in Austria that focuses on the veterinary sciences. About 1000 employees and 2300 students work on the campus in the north of Vienna, which also houses the animal hospital and various spin-off-companies. http://www.vetmeduni.ac.at
Scientific contact:
Prof. Veronika Sexl
Institute of Pharmacology and Toxicology
University of Veterinary Medicine, Vienna
T +43 1 25077-2910
Veronika.Sexl@vetmeduni.ac.at
Distributed by:
Klaus Wassermann
Public Relations/Science Communication
University of Veterinary Medicine, Vienna
T +43 1 25077-1153
Klaus.Wassermann@vetmeduni.ac.at
[ | E-mail | Share ] ?
AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.
Source: http://www.eurekalert.org/pub_releases/2012-10/uovm-oma101512.php
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Sunday, October 14, 2012
Order Now - Windows 8 Pro DVD Pack, Upgrade from Windows 7 ...
We are ready for another desktop operating system release from Microsoft, this time Windows 8 comes with improved performance, different interface and new features too. Amazon the online shopping store started to accept orders for Windows 8 pro DVD pack which can be used for new installation and upgrade from Windows 7, Vista and XP. Definitely Windows 8 will be a hit like Windows XP and Windows 7 on respective released years.
Sysprobs covered several guides and articles about Windows 8 here is this page. I?m using Windows 8 for testing purpose since it was available for public as beta version. It is one of the great OS from Microsoft with fast booting and working performance. Once you install on the system, I?m sure you will see the performance difference on same PC between your old OS and new Windows 8, in good way.
Click here to order Windows 8 pro DVD pack and free delivery from Amazon (to some areas only)
The final version of Windows 8 will be available for download from October 26th when it is launched officially. I know there are people crazy on having DVD and software box of their favorite OS, applications and games, if you are one of them, order Windows 8 Pro DVD pack now.
Any customer who buys or already purchased a Windows 7 PC between June 2 2012 and the end of January 2013 will be able to get upgrade to Windows 8 pro just for $15, that?s really cool. This is make sure current PC sales with Windows 7 doesn?t get effect.
For Windows 8 installation, your computer should support Hardware Virtualization Technology (VT) and NX/ND enabled processors. Mostly the all latest computers have this feature now, if your computer is pretty old, better check this requirement before order. You can refer following guides,
How to enable Virtualization Technology (VT)
How to enable NX/XD
Source: http://www.sysprobs.com/order-now-windows-8-pro-dvd-pack-upgrade-from-windows-7-vista-and-xp
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Saturday, October 13, 2012
Fast Weight Loss Part 1 for High Intensity Cardio | Bodybuilding ...
Learn the most powerful cardio workout that will help you lose weight fast and get ripped. Did you enjoy the ?High Intensity Cardio for Fast Weight Loss Part 1? video? For the web?s best Six Pack ABS Workout & Exercise Videos.
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